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10.1016/j.cell.2017.08.017 http://scihub22266oqcxt.onion/10.1016/j.cell.2017.08.017 C5610175!5610175 !28938124     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28938124 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell 2017 ; 171 (1 ): 72-84.e13 Nephropedia Template TP {{tp|p=28938124 |t=2017. The Kinetochore Receptor for the Cohesin Loading Complex |pdf=|usr=}}{{28938124 }} gab.com Text The Kinetochore Receptor for the Cohesin Loading Complex JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=28938124 #FOAvip The ring-shaped cohesin complex brings together distant DNA domains to maintain, express, and segregate the genome. Establishing specific chromosomal linkages depends on cohesin recruitment to defined loci. One such locus is the budding yeast centromere, which is a paradigm for targeted cohesin loading. The kinetochore, a multiprotein complex that connects centromeres to microtubules, drives the recruitment of high levels of cohesin to link sister chromatids together. We have exploited this system to determine the mechanism of specific cohesin recruitment. We show that phosphorylation of the Ctf19 kinetochore protein by a conserved kinase, DDK, provides a binding site for the Scc2/4 cohesin loading complex, thereby directing cohesin loading to centromeres. A similar mechanism targets cohesin to chromosomes in vertebrates. These findings represent a complete molecular description of targeted cohesin loading, a phenomenon with wide-ranging importance in chromosome segregation and, in multicellular organisms, transcription regulation. Twit Text FOAVip The Kinetochore Receptor for the Cohesin Loading Complex ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=28938124 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28938124 #FOAvip English Wikipedia <ref>{{Cite pmid|28938124 }}</ref> The Kinetochore Receptor for the Cohesin Loading Complex #MMPMID28938124 Hinshaw SM ; Makrantoni V ; Harrison SC ; Marston AL Cell 2017[Sep]; 171 (1 ): 72-84.e13 PMID28938124 show ga The ring-shaped cohesin complex brings together distant DNA domains to maintain, express, and segregate the genome. Establishing specific chromosomal linkages depends on cohesin recruitment to defined loci. One such locus is the budding yeast centromere, which is a paradigm for targeted cohesin loading. The kinetochore, a multiprotein complex that connects centromeres to microtubules, drives the recruitment of high levels of cohesin to link sister chromatids together. We have exploited this system to determine the mechanism of specific cohesin recruitment. We show that phosphorylation of the Ctf19 kinetochore protein by a conserved kinase, DDK, provides a binding site for the Scc2/4 cohesin loading complex, thereby directing cohesin loading to centromeres. A similar mechanism targets cohesin to chromosomes in vertebrates. These findings represent a complete molecular description of targeted cohesin loading, a phenomenon with wide-ranging importance in chromosome segregation and, in multicellular organisms, transcription regulation. |Cell Cycle Proteins/*metabolism [MESH] |Centromere/metabolism [MESH] |Chromosomal Proteins, Non-Histone/*metabolism [MESH] |Cohesins [MESH] |Cytoskeletal Proteins/metabolism [MESH] |Kinetochores/*metabolism [MESH] |Multiprotein Complexes/metabolism [MESH] |Phosphorylation [MESH] |Phylogeny [MESH] |Saccharomyces cerevisiae Proteins/metabolism [MESH] |Saccharomyces cerevisiae/cytology/*metabolism [MESH]The Kinetochore Receptor for the Cohesin Loading Complex (epmc).pdf DeepDyve Pubget Overpricing