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The Interleukin-20 Cytokines in Intestinal Diseases
#MMPMID29967613
Niess JH
; Hruz P
; Kaymak T
Front Immunol
2018[]; 9
(?): 1373
PMID29967613
show ga
Autoimmune/inflammatory intestinal diseases, such as Crohn's disease and
ulcerative colitis, infectious gastrointestinal diseases, and gastrointestinal
cancers, such as colorectal cancer, are worldwide a significant health problem.
Intercellular communication and direct contact with the environment as the
microbiota colonizes the gastrointestinal surface facilitates these diseases.
Cytokines mediate the intercellular communication to maintain the equilibrium
between host and environment and to regulate immune responses. One cytokine
family that exchange information between immune cells and epithelial cells is the
IL-20 cytokine family which includes the cytokines IL-19, IL-20, IL-22, IL-24,
and IL-26. These cytokines share common receptor subunits and signaling pathways.
IL-22 is the most intensively studied cytokine within this family in contexts of
gastrointestinal disease, but the importance of other family members is more and
more appreciated. In this review, the potential function of IL-20 cytokines
concerning gastrointestinal conditions is discussed.
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