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2016 ; 27
(5
): 1389-99
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The Influence of CKD on Colonic Microbial Metabolism
#MMPMID26400570
Poesen R
; Windey K
; Neven E
; Kuypers D
; De Preter V
; Augustijns P
; D'Haese P
; Evenepoel P
; Verbeke K
; Meijers B
J Am Soc Nephrol
2016[May]; 27
(5
): 1389-99
PMID26400570
show ga
There is increasing interest in the colonic microbiota as a relevant source of
uremic retention solutes accumulating in CKD. Renal disease can also profoundly
affect the colonic microenvironment and has been associated with a distinct
colonic microbial composition. However, the influence of CKD on the colonic
microbial metabolism is largely unknown. Therefore, we studied fecal metabolite
profiles of hemodialysis patients and healthy controls using a gas
chromatography-mass spectrometry method. We observed a clear discrimination
between both groups, with 81 fecal volatile organic compounds detected at
significantly different levels in hemodialysis patients and healthy controls. To
further explore the differential impact of renal function loss per se versus the
effect of dietary and other CKD-related factors, we also compared fecal
metabolite profiles between patients on hemodialysis and household contacts on
the same diet, which revealed a close resemblance. In contrast, significant
differences were noted between the fecal samples of rats 6 weeks after 5/6th
nephrectomy and those of sham-operated rats, still suggesting an independent
influence of renal function loss. Thus, CKD associates with a distinct colonic
microbial metabolism, although the effect of renal function loss per se in humans
may be inferior to the effects of dietary and other CKD-related factors. The
potential beneficial effect of therapeutics targeting colonic microbiota in
patients with CKD remains to be examined.
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