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2016 ; 6
(6
): 513-521
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The Ikaros family of zinc-finger proteins
#MMPMID27818917
Fan Y
; Lu D
Acta Pharm Sin B
2016[Nov]; 6
(6
): 513-521
PMID27818917
show ga
Ikaros represents a zinc-finger protein family important for lymphocyte
development and certain other physiological processes. The number of family
members is large, with alternative splicing producing various additional isoforms
from each of the five homologous genes in the family. The functional forms of
Ikaros proteins could be even more diverse due to protein-protein interactions
readily established between family members. Emerging evidence suggests that
targeting Ikaros proteins is feasible and effective in therapeutic applications,
although the exact roles of Ikaros proteins remain elusive within the intricate
regulatory networks in which they are involved. In this review we collect
existing knowledge as to the functions, regulatory pathways, and molecular
mechanisms of this family of proteins in an attempt to gain a better
understanding through the comparison of activities and interactions among family
members.