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2016 ; 12
(3
): 401-7
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The Humanistic and Economic Burden of Narcolepsy
#MMPMID26518705
Flores NM
; Villa KF
; Black J
; Chervin RD
; Witt EA
J Clin Sleep Med
2016[Mar]; 12
(3
): 401-7
PMID26518705
show ga
STUDY OBJECTIVES: To evaluate the burden of narcolepsy--with respect to
psychiatric comorbidities, Health-Related Quality of Life (HRQoL), direct costs
for healthcare resource utilization, and indirect costs for reported work
loss-through comparison of patients to matched controls. METHODS: This analysis
was conducted on data from the 2011, 2012, and 2013 US National Health and
Wellness Survey (NHWS; 2011 NHWS n = 75,000, 2012 NHWS n = 71,157, and 2013 NHWS
n = 75,000). Patients who reported a narcolepsy diagnosis (n = 437) were matched
1:2 with controls (n = 874) on age, sex, race/ethnicity, marital status,
education, household income, body mass index, smoking status, alcohol use,
exercise, and physical comorbidity. Chi-square tests and one-way analyses of
variance were used to assess whether the narcolepsy and control groups differed
on psychiatric comorbidities, HRQoL, labor force participation, work
productivity, and healthcare resource utilization. RESULTS: Patients with
narcolepsy, in comparison to matched controls, reported substantially (two to
four times) greater psychiatric comorbidity, HRQoL impairment, prevalence of
long-term disability, absenteeism, and presenteeism, and greater resource use in
the past 6 mo as indicated by higher mean number of hospitalizations, emergency
department visits, traditional healthcare professional visits, neurologist
visits, and psychiatrist visits (each p < 0.05). CONCLUSIONS: These
population-based data suggest that a narcolepsy diagnosis is associated with
substantial adverse impact on mental health, HRQoL, and key economic burdens that
include work impairment, resource use, and both direct and indirect costs.
Although this study is cross-sectional, the results highlight the magnitude of
the potential opportunity to improve mental health, lower costs, and augment
work-related productivity through effective assessment and treatment of
narcolepsy.
|*Cost of Illness
[MESH]
|*Health Status
[MESH]
|Absenteeism
[MESH]
|Cross-Sectional Studies
[MESH]
|Delivery of Health Care/statistics & numerical data
[MESH]
|Female
[MESH]
|Health Surveys/statistics & numerical data
[MESH]
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