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The Hippo pathway in tissue homeostasis and regeneration
#MMPMID28130761
Wang Y
; Yu A
; Yu FX
Protein Cell
2017[May]; 8
(5
): 349-359
PMID28130761
show ga
While several organs in mammals retain partial regenerative capability following
tissue damage, the underlying mechanisms remain unclear. Recently, the Hippo
signaling pathway, better known for its function in organ size control, has been
shown to play a pivotal role in regulating tissue homeostasis and regeneration.
Upon tissue injury, the activity of YAP, the major effector of the Hippo pathway,
is transiently induced, which in turn promotes expansion of tissue-resident
progenitors and facilitates tissue regeneration. In this review, with a general
focus on the Hippo pathway, we will discuss its major components, functions in
stem cell biology, involvement in tissue regeneration in different organs, and
potential strategies for developing Hippo pathway-targeted regenerative
medicines.
|Adaptor Proteins, Signal Transducing/metabolism
[MESH]
free
free
free
