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2018 ; 10
(4
): ä Nephropedia Template TP
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The Hippo Pathway: Immunity and Cancer
#MMPMID29597279
Taha Z
; Janse van Rensburg HJ
; Yang X
Cancers (Basel)
2018[Mar]; 10
(4
): ä PMID29597279
show ga
Since its discovery, the Hippo pathway has emerged as a central signaling network
in mammalian cells. Canonical signaling through the Hippo pathway core components
(MST1/2, LATS1/2, YAP and TAZ) is important for development and tissue
homeostasis while aberrant signaling through the Hippo pathway has been
implicated in multiple pathologies, including cancer. Recent studies have
uncovered new roles for the Hippo pathway in immunology. In this review, we
summarize the mechanisms by which Hippo signaling in pathogen-infected or
neoplastic cells affects the activities of immune cells that respond to these
threats. We further discuss how Hippo signaling functions as part of an immune
response. Finally, we review how immune cell-intrinsic Hippo signaling modulates
the development/function of leukocytes and propose directions for future work.