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2015 ; 22
(ä): 99
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The HRASLS (PLA/AT) subfamily of enzymes
#MMPMID26503625
Mardian EB
; Bradley RM
; Duncan RE
J Biomed Sci
2015[Oct]; 22
(ä): 99
PMID26503625
show ga
The H-RAS-like suppressor (HRASLS) subfamily consists of five enzymes (1-5) in
humans and three (1, 3, and 5) in mice and rats that share sequence homology with
lecithin:retinol acyltransferase (LRAT). All HRASLS family members possess in
vitro phospholipid metabolizing abilities including phospholipase A1/2 (PLA1/2)
activities and O-acyltransferase activities for the remodeling of
glycerophospholipid acyl chains, as well as N-acyltransferase activities for the
production of N-acylphosphatidylethanolamines. The in vivo biological activities
of the HRASLS enzymes have not yet been fully investigated. Research to date
indicates involvement of this subfamily in a wide array of biological processes
and, as a consequence, these five enzymes have undergone extensive rediscovery
and renaming within different fields of research. This review briefly describes
the discovery of each of the HRASLS enzymes and their role in cancer, and
discusses the biochemical function of each enzyme, as well as the biological
role, if known. Gaps in current understanding are highlighted and suggestions for
future research directions are discussed.
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