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2018 ; 9
(ä): 296
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The Genome-Scale Integrated Networks in Microorganisms
#MMPMID29527198
Hao T
; Wu D
; Zhao L
; Wang Q
; Wang E
; Sun J
Front Microbiol
2018[]; 9
(ä): 296
PMID29527198
show ga
The genome-scale cellular network has become a necessary tool in the systematic
analysis of microbes. In a cell, there are several layers (i.e., types) of the
molecular networks, for example, genome-scale metabolic network (GMN),
transcriptional regulatory network (TRN), and signal transduction network (STN).
It has been realized that the limitation and inaccuracy of the prediction exist
just using only a single-layer network. Therefore, the integrated network
constructed based on the networks of the three types attracts more interests. The
function of a biological process in living cells is usually performed by the
interaction of biological components. Therefore, it is necessary to integrate and
analyze all the related components at the systems level for the comprehensively
and correctly realizing the physiological function in living organisms. In this
review, we discussed three representative genome-scale cellular networks: GMN,
TRN, and STN, representing different levels (i.e., metabolism, gene regulation,
and cellular signaling) of a cell's activities. Furthermore, we discussed the
integration of the networks of the three types. With more understanding on the
complexity of microbial cells, the development of integrated network has become
an inevitable trend in analyzing genome-scale cellular networks of
microorganisms.