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10.3390/ijms161125990

http://scihub22266oqcxt.onion/10.3390/ijms161125990
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C4661849!4661849 !26569220
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suck abstract from ncbi


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pmid26569220
      Int+J+Mol+Sci 2015 ; 16 (11 ): 26797-812
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  • The Function of Autophagy in Neurodegenerative Diseases #MMPMID26569220
  • Kiriyama Y ; Nochi H
  • Int J Mol Sci 2015[Nov]; 16 (11 ): 26797-812 PMID26569220 show ga
  • Macroautophagy, hereafter referred to as autophagy, is a bulk degradation process performed by lysosomes in which aggregated and altered proteins as well as dysfunctional organelles are decomposed. Autophagy is a basic cellular process that maintains homeostasis and is crucial for postmitotic neurons. Thus, impaired autophagic processes in neurons lead to improper homeostasis and neurodegeneration. Recent studies have suggested that impairments of the autophagic process are associated with several neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and static encephalopathy of childhood with neurodegeneration in adulthood. In this review, we focus on the recent findings regarding the autophagic process and the involvement of autophagy in neurodegenerative diseases.
  • |AMP-Activated Protein Kinases/genetics/metabolism [MESH]
  • |Alzheimer Disease/*genetics/metabolism/pathology [MESH]
  • |Amyotrophic Lateral Sclerosis/*genetics/metabolism/pathology [MESH]
  • |Apoptosis Regulatory Proteins/genetics/metabolism [MESH]
  • |Autophagy-Related Protein-1 Homolog [MESH]
  • |Autophagy/*genetics [MESH]
  • |Beclin-1 [MESH]
  • |Gene Expression Regulation [MESH]
  • |Humans [MESH]
  • |Huntington Disease/*genetics/metabolism/pathology [MESH]
  • |Intracellular Signaling Peptides and Proteins/genetics/metabolism [MESH]
  • |Lysosomes/metabolism [MESH]
  • |Mechanistic Target of Rapamycin Complex 1 [MESH]
  • |Membrane Proteins/genetics/metabolism [MESH]
  • |Multiprotein Complexes/genetics/metabolism [MESH]
  • |Neurons/metabolism/pathology [MESH]
  • |Parkinson Disease/*genetics/metabolism/pathology [MESH]
  • |Protein Serine-Threonine Kinases/genetics/metabolism [MESH]
  • |Signal Transduction [MESH]


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