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2015 ; 16
(11
): 26797-812
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The Function of Autophagy in Neurodegenerative Diseases
#MMPMID26569220
Kiriyama Y
; Nochi H
Int J Mol Sci
2015[Nov]; 16
(11
): 26797-812
PMID26569220
show ga
Macroautophagy, hereafter referred to as autophagy, is a bulk degradation process
performed by lysosomes in which aggregated and altered proteins as well as
dysfunctional organelles are decomposed. Autophagy is a basic cellular process
that maintains homeostasis and is crucial for postmitotic neurons. Thus, impaired
autophagic processes in neurons lead to improper homeostasis and
neurodegeneration. Recent studies have suggested that impairments of the
autophagic process are associated with several neurodegenerative diseases, such
as Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic
lateral sclerosis, and static encephalopathy of childhood with neurodegeneration
in adulthood. In this review, we focus on the recent findings regarding the
autophagic process and the involvement of autophagy in neurodegenerative
diseases.
|AMP-Activated Protein Kinases/genetics/metabolism
[MESH]