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10.1021/acs.jmedchem.6b00975 http://scihub22266oqcxt.onion/10.1021/acs.jmedchem.6b00975 C5346970!5346970 !28074653     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28074653 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28074653 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Med+Chem 2017 ; 60 (5 ): 1620-1637 Nephropedia Template TP {{tp|p=28074653 |t=2017. The Essential Medicinal Chemistry of Curcumin |pdf=|usr=}}{{28074653 }} gab.com Text The Essential Medicinal Chemistry of Curcumin JO: J Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=28074653 #FOAvip Curcumin is a constituent (up to ?5%) of the traditional medicine known as turmeric. Interest in the therapeutic use of turmeric and the relative ease of isolation of curcuminoids has led to their extensive investigation. Curcumin has recently been classified as both a PAINS (pan-assay interference compounds) and an IMPS (invalid metabolic panaceas) candidate. The likely false activity of curcumin in vitro and in vivo has resulted in >120 clinical trials of curcuminoids against several diseases. No double-blinded, placebo controlled clinical trial of curcumin has been successful. This manuscript reviews the essential medicinal chemistry of curcumin and provides evidence that curcumin is an unstable, reactive, nonbioavailable compound and, therefore, a highly improbable lead. On the basis of this in-depth evaluation, potential new directions for research on curcuminoids are discussed. Twit Text FOAVip The Essential Medicinal Chemistry of Curcumin ????J Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=28074653 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28074653 #FOAvip English Wikipedia <ref>{{Cite pmid|28074653 }}</ref> The Essential Medicinal Chemistry of Curcumin #MMPMID28074653 Nelson KM ; Dahlin JL ; Bisson J ; Graham J ; Pauli GF ; Walters MA J Med Chem 2017[Mar]; 60 (5 ): 1620-1637 PMID28074653 show ga Curcumin is a constituent (up to ?5%) of the traditional medicine known as turmeric. Interest in the therapeutic use of turmeric and the relative ease of isolation of curcuminoids has led to their extensive investigation. Curcumin has recently been classified as both a PAINS (pan-assay interference compounds) and an IMPS (invalid metabolic panaceas) candidate. The likely false activity of curcumin in vitro and in vivo has resulted in >120 clinical trials of curcuminoids against several diseases. No double-blinded, placebo controlled clinical trial of curcumin has been successful. This manuscript reviews the essential medicinal chemistry of curcumin and provides evidence that curcumin is an unstable, reactive, nonbioavailable compound and, therefore, a highly improbable lead. On the basis of this in-depth evaluation, potential new directions for research on curcuminoids are discussed. |*Chemistry, Pharmaceutical [MESH] |Animals [MESH] |Curcumin/chemistry/pharmacokinetics/*pharmacology [MESH]The Essential Medicinal Chemistry of Curcumin (epmc).pdf DeepDyve Pubget Overpricing