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2017 ; 13
(9
): 1118-1125
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The Emerging Roles of Microparticles in Diabetic Nephropathy
#MMPMID29104503
Lu CC
; Ma KL
; Ruan XZ
; Liu BC
Int J Biol Sci
2017[]; 13
(9
): 1118-1125
PMID29104503
show ga
Microparticles (MPs) are a type of extracellular vesicles (EVs) shed from the
outward budding of plasma membranes during cell apoptosis and/or activation.
These microsized particles then release specific contents (e.g., lipids,
proteins, microRNAs) which are active participants in a wide range of both
physiological and pathological processes at the molecular level, e.g.,
coagulation and angiogenesis, inflammation, immune responses. Research
limitations, such as confusing nomenclature and overlapping classification, have
impeded our comprehension of these tiny molecules. Diabetic nephropathy (DN) is
currently the greatest contributor to end-stage renal diseases (ESRD) worldwide,
and its public health impact will continue to grow due to the persistent increase
in the prevalence of diabetes mellitus (DM). MPs have recently been considered as
potentially involved in DN onset and progression, and this review juxtaposes some
of the research updates about the possible mechanisms from several relevant
aspects and insights into the therapeutic perspectives of MPs in clinical
management and pharmacological treatment of DN patients.
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