10.1002/jcp.25676 http://scihub22266oqcxt.onion/10.1002/jcp.25676 C5347962!5347962
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J+Cell+Physiol
2017 ; 232
(6
): 1233-1238
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The Emerging Role of TRAF7 in Tumor Development
#MMPMID27808423
Zotti T
; Scudiero I
; Vito P
; Stilo R
J Cell Physiol
2017[Jun]; 232
(6
): 1233-1238
PMID27808423
show ga
The seven members of the tumor necrosis factor receptor (TNF-R)-associated factor
(TRAF) family of intracellular proteins were originally discovered and
characterized as signaling adaptor molecules coupled to the cytoplasmic regions
of receptors of the TNF-R superfamily. Functionally, TRAFs act both as a scaffold
and/or enzymatic proteins to regulate activation of mitogen-activated protein
kinases (MAPKs) and transcription factors of nuclear factor-?B family (NF-?B).
Given the wide variety of stimuli intracellularly conveyed by TRAF proteins, they
are physiologically involved in multiple biological processes, including
embryonic development, tissue homeostasis, and regulation of innate and adaptive
immune responses. In the last few years, it has become increasingly evident the
involvement of TRAF7, the last member of the TRAF family to be discovered, in the
genesis and progression of several human cancers, placing TRAF7 in the spotlight
as a novel tumor suppressor protein. In this paper, we review and discuss the
literature recently produced on this subject. J. Cell. Physiol. 232: 1233-1238,
2017. © 2016 The Authors. Journal of Cellular Physiology Published by Wiley
Periodicals, Inc.
Please enable JavaScript to view the comments powered by Disqus. |Animals
[MESH] |Carcinogenesis/*metabolism/*pathology
[MESH] |Humans
[MESH] |Models, Biological
[MESH] |Mutation/genetics
[MESH] |Neoplasms/*metabolism/*pathology
[MESH] |Protein Domains
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