The Emerging Facets of Non-Cancerous Warburg Effect
#MMPMID29109698
Abdel-Haleem AM
; Lewis NE
; Jamshidi N
; Mineta K
; Gao X
; Gojobori T
Front Endocrinol (Lausanne)
2017[]; 8
(?): 279
PMID29109698
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The Warburg effect (WE), or aerobic glycolysis, is commonly recognized as a
hallmark of cancer and has been extensively studied for potential anti-cancer
therapeutics development. Beyond cancer, the WE plays an important role in many
other cell types involved in immunity, angiogenesis, pluripotency, and infection
by pathogens (e.g., malaria). Here, we review the WE in non-cancerous context as
a "hallmark of rapid proliferation." We observe that the WE operates in rapidly
dividing cells in normal and pathological states that are triggered by internal
and external cues. Aerobic glycolysis is also the preferred metabolic program in
the cases when robust transient responses are needed. We aim to draw attention to
the potential of computational modeling approaches in systematic characterization
of common metabolic features beyond the WE across physiological and pathological
conditions. Identification of metabolic commonalities across various diseases may
lead to successful repurposing of drugs and biomarkers.
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