Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29731754
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Front+Immunol
2018 ; 9
(ä): 796
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
The Emerging Complexity of ??T17 Cells
#MMPMID29731754
McKenzie DR
; Comerford I
; Silva-Santos B
; McColl SR
Front Immunol
2018[]; 9
(ä): 796
PMID29731754
show ga
Preprogrammed IL-17-producing ?? T cells constitute a poorly understood class of
lymphocytes that express rearranged antigen receptors but appear to make little
use of them. ??T17 cells were first characterized as tissue-resident sentinels
with innate effector function. However, ongoing research continues to reveal
unexpected complexity to this unusual subset, including phenotypic plasticity,
memory-like activity and unique migratory behavior. Despite these advances, at
the core of ??T17 cell biology remain fundamental gaps in knowledge: Are ??T17
cells truly innate or has the importance of the T cell receptor been overlooked?
How unique are they among IL-17-producing lymphocytes? How similar are these
cells between mice and humans? We speculate that answering these unresolved
questions is key to successful manipulation of ?? T cells in clinical settings.