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10.3389/fimmu.2018.00796

http://scihub22266oqcxt.onion/10.3389/fimmu.2018.00796
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C5919943!5919943 !29731754
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suck abstract from ncbi


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pmid29731754
      Front+Immunol 2018 ; 9 (ä): 796
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  • The Emerging Complexity of ??T17 Cells #MMPMID29731754
  • McKenzie DR ; Comerford I ; Silva-Santos B ; McColl SR
  • Front Immunol 2018[]; 9 (ä): 796 PMID29731754 show ga
  • Preprogrammed IL-17-producing ?? T cells constitute a poorly understood class of lymphocytes that express rearranged antigen receptors but appear to make little use of them. ??T17 cells were first characterized as tissue-resident sentinels with innate effector function. However, ongoing research continues to reveal unexpected complexity to this unusual subset, including phenotypic plasticity, memory-like activity and unique migratory behavior. Despite these advances, at the core of ??T17 cell biology remain fundamental gaps in knowledge: Are ??T17 cells truly innate or has the importance of the T cell receptor been overlooked? How unique are they among IL-17-producing lymphocytes? How similar are these cells between mice and humans? We speculate that answering these unresolved questions is key to successful manipulation of ?? T cells in clinical settings.
  • |Animals [MESH]
  • |Humans [MESH]
  • |Interleukin-17/immunology [MESH]
  • |Mice [MESH]
  • |Receptors, Antigen, T-Cell, gamma-delta/*immunology [MESH]


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