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2017 ; 81
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The Ecology of Prions
#MMPMID28566466
Zabel M
; Ortega A
Microbiol Mol Biol Rev
2017[Sep]; 81
(3
): ä PMID28566466
show ga
Chronic wasting disease (CWD) affects cervids and is the only known prion disease
readily transmitted among free-ranging wild animal populations in nature. The
increasing spread and prevalence of CWD among cervid populations threaten the
survival of deer and elk herds in North America, and potentially beyond. This
review focuses on prion ecology, specifically that of CWD, and the current
understanding of the role that the environment may play in disease propagation.
We recount the discovery of CWD, discuss the role of the environment in indirect
CWD transmission, and consider potentially relevant environmental reservoirs and
vectors. We conclude by discussing how understanding the environmental
persistence of CWD lends insight into transmission dynamics and potential
management and mitigation strategies.