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2016 ; 38
(2
): 147-60
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The Dynamics of Apoptotic Cell Clearance
#MMPMID27459067
Elliott MR
; Ravichandran KS
Dev Cell
2016[Jul]; 38
(2
): 147-60
PMID27459067
show ga
The phagocytic clearance of dying cells in a tissue is a highly orchestrated
series of intercellular events coordinated by a complex signaling network. Recent
data from genetic, biochemical, and live-imaging approaches have greatly enhanced
our understanding of the dynamics of cell clearance and how the process is
orchestrated at the cellular and tissue levels. We discuss how networks
regulating apoptotic cell clearance are integrated to enable a rapid, efficient,
and high-capacity clearance system within tissues.