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2015 ; 4
(6
): 961-6
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The Dynamic Duo: Niche/Stem Cell Interdependency
#MMPMID26028534
Mesa KR
; Rompolas P
; Greco V
Stem Cell Reports
2015[Jun]; 4
(6
): 961-6
PMID26028534
show ga
Most tissues in our bodies undergo constant cellular turnover. This process
requires a dynamic balance between cell production and elimination. Stem cells
have been shown in many of these tissues to be the major source of new cells.
However, despite the tremendous advances made, it still remains unclear how stem
cell behavior and activity are regulated in vivo. Furthermore, we lack basic
understanding for the mechanisms that coordinate niche/stem cell interactions to
maintain normal tissue homeostasis. Our lab has established a novel imaging
approach in live mice using the skin as a model system to investigate these
fundamental processes in both physiological and pathological settings such as
cancer, with the goal of understanding how tissues successfully orchestrate
tissue regeneration throughout the lifetime of an organism.