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2018 ; 10
(6
): ä Nephropedia Template TP
gab.com Text
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The Diversity of Bacterial Lifestyles Hampers Bacteriophage Tenacity
#MMPMID29914064
Lourenço M
; De Sordi L
; Debarbieux L
Viruses
2018[Jun]; 10
(6
): ä PMID29914064
show ga
Phage therapy is based on a simple concept: the use of a virus (bacteriophage)
that is capable of killing specific pathogenic bacteria to treat bacterial
infections. Since the pioneering work of Félix d’Herelle,
bacteriophages (phages) isolated in vitro have been shown to be of therapeutic
value. Over decades of study, a large number of rather complex mechanisms that
are used by phages to hijack bacterial resources and to produce their progeny
have been deciphered. While these mechanisms have been identified and have been
studied under optimal conditions in vitro, much less is known about the
requirements for successful viral infections in relevant natural conditions. This
is particularly true in the context of phage therapy. Here, we highlight the
parameters affecting phage replication in both in vitro and in vivo environments,
focusing, in particular, on the mammalian digestive tract. We propose avenues for
increasing the knowledge-guided implementation of phages as therapeutic tools.
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