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10.3390/ijms17050638

http://scihub22266oqcxt.onion/10.3390/ijms17050638
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C4881464!4881464 !27136533
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suck abstract from ncbi


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pmid27136533
      Int+J+Mol+Sci 2016 ; 17 (5 ): ä
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  • The Dark Side of Cell Fusion #MMPMID27136533
  • Bastida-Ruiz D ; Van Hoesen K ; Cohen M
  • Int J Mol Sci 2016[Apr]; 17 (5 ): ä PMID27136533 show ga
  • Cell fusion is a physiological cellular process essential for fertilization, viral entry, muscle differentiation and placental development, among others. In this review, we will highlight the different cancer cell-cell fusions and the advantages obtained by these fusions. We will specially focus on the acquisition of metastatic features by cancer cells after fusion with bone marrow-derived cells. The mechanism by which cancer cells fuse with other cells has been poorly studied thus far, but the presence in several cancer cells of syncytin, a trophoblastic fusogen, leads us to a cancer cell fusion mechanism similar to the one used by the trophoblasts. The mechanism by which cancer cells perform the cell fusion could be an interesting target for cancer therapy.
  • |Bone Marrow Cells/*cytology/metabolism [MESH]
  • |Cell Fusion [MESH]
  • |Gene Products, env/metabolism [MESH]
  • |Humans [MESH]
  • |Models, Biological [MESH]
  • |Neoplasm Metastasis [MESH]
  • |Neoplastic Cells, Circulating/metabolism [MESH]
  • |Neoplastic Stem Cells/*cytology/metabolism [MESH]
  • |Pregnancy Proteins/metabolism [MESH]


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