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2016 ; 17
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): ä Nephropedia Template TP
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The Dark Side of Cell Fusion
#MMPMID27136533
Bastida-Ruiz D
; Van Hoesen K
; Cohen M
Int J Mol Sci
2016[Apr]; 17
(5
): ä PMID27136533
show ga
Cell fusion is a physiological cellular process essential for fertilization,
viral entry, muscle differentiation and placental development, among others. In
this review, we will highlight the different cancer cell-cell fusions and the
advantages obtained by these fusions. We will specially focus on the acquisition
of metastatic features by cancer cells after fusion with bone marrow-derived
cells. The mechanism by which cancer cells fuse with other cells has been poorly
studied thus far, but the presence in several cancer cells of syncytin, a
trophoblastic fusogen, leads us to a cancer cell fusion mechanism similar to the
one used by the trophoblasts. The mechanism by which cancer cells perform the
cell fusion could be an interesting target for cancer therapy.