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10.1016/j.bpj.2016.07.037 http://scihub22266oqcxt.onion/10.1016/j.bpj.2016.07.037 C5018137!5018137 !27602719     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27602719 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Biophys+J 2016 ; 111 (5 ): 909-16 Nephropedia Template TP {{tp|p=27602719 |t=2016. The Dark Matter of Biology |pdf=|usr=}}{{27602719 }} gab.com Text The Dark Matter of Biology JO: Biophys J http://www.kidney.de/pget.php?&tw=1&pmid=27602719 #FOAvip The inside of the cell is full of important, yet invisible species of molecules and proteins that interact weakly but couple together to have huge and important effects in many biological processes. Such "dark matter" inside cells remains mostly hidden, because our tools were developed to investigate strongly interacting species and folded proteins. Example dark-matter species include intrinsically disordered proteins, posttranslational states, ion species, and rare, transient, and weak interactions undetectable by biochemical assays. The dark matter of biology is likely to have multiple, vital roles to regulate signaling, rates of reactions, water structure and viscosity, crowding, and other cellular activities. We need to create new tools to image, detect, and understand these dark-matter species if we are to truly understand fundamental physical principles of biology. Twit Text FOAVip The Dark Matter of Biology ????Biophys J http://www.kidney.de/pget.php?&tw=1&pmid=27602719 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27602719 #FOAvip English Wikipedia <ref>{{Cite pmid|27602719 }}</ref> The Dark Matter of Biology #MMPMID27602719 Ross JL Biophys J 2016[Sep]; 111 (5 ): 909-16 PMID27602719 show ga The inside of the cell is full of important, yet invisible species of molecules and proteins that interact weakly but couple together to have huge and important effects in many biological processes. Such "dark matter" inside cells remains mostly hidden, because our tools were developed to investigate strongly interacting species and folded proteins. Example dark-matter species include intrinsically disordered proteins, posttranslational states, ion species, and rare, transient, and weak interactions undetectable by biochemical assays. The dark matter of biology is likely to have multiple, vital roles to regulate signaling, rates of reactions, water structure and viscosity, crowding, and other cellular activities. We need to create new tools to image, detect, and understand these dark-matter species if we are to truly understand fundamental physical principles of biology. |Animals [MESH] |Biophysical Phenomena [MESH] |Humans [MESH] |Intracellular Space/*chemistry/metabolism [MESH] |Ions/chemistry/metabolism [MESH] |Protein Processing, Post-Translational [MESH] |Proteins/chemistry/metabolism [MESH]The Dark Matter of Biology (epmc).pdf DeepDyve Pubget Overpricing