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2017 ; 27
(8
): R318-R326
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The Cytoskeleton-Autophagy Connection
#MMPMID28441569
Kast DJ
; Dominguez R
Curr Biol
2017[Apr]; 27
(8
): R318-R326
PMID28441569
show ga
Actin cytoskeleton dynamics play vital roles in most forms of intracellular
trafficking by promoting the biogenesis and transport of vesicular cargoes.
Mounting evidence indicates that actin dynamics and membrane-cytoskeleton
scaffolds also have essential roles in macroautophagy, the process by which
cellular waste is isolated inside specialized vesicles called autophagosomes for
recycling and degradation. Branched actin polymerization is necessary for the
biogenesis of autophagosomes from the endoplasmic reticulum (ER) membrane.
Actomyosin-based transport is then used to feed the growing phagophore with
pre-selected cargoes and debris derived from different membranous organelles
inside the cell. Finally, mature autophagosomes detach from the ER membrane by an
as yet unknown mechanism, undergo intracellular transport and then fuse with
lysosomes, endosomes and multivesicular bodies through mechanisms that involve
actin- and microtubule-mediated motility, cytoskeleton-membrane scaffolds and
signaling proteins. In this review, we highlight the considerable progress made
recently towards understanding the diverse roles of the cytoskeleton in
autophagy.
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