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10.1007/s00221-017-4905-8 http://scihub22266oqcxt.onion/10.1007/s00221-017-4905-8 C5380693!5380693 !28246967     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28246967 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Exp+Brain+Res 2017 ; 235 (5 ): 1455-1465 Nephropedia Template TP {{tp|p=28246967 |t=2017. The Cognitive Role of the Globus Pallidus interna; Insights from Disease States |pdf=|usr=}}{{28246967 }} gab.com Text The Cognitive Role of the Globus Pallidus interna; Insights from Disease States JO: Exp Brain Res http://www.kidney.de/pget.php?&tw=1&pmid=28246967 #FOAvip The motor symptoms of both Parkinson's disease and focal dystonia arise from dysfunction of the basal ganglia, and are improved by pallidotomy or deep brain stimulation of the Globus Pallidus interna (GPi). However, Parkinson's disease is associated with a greater degree of basal ganglia-dependent learning impairment than dystonia. We attempt to understand this observation in terms of a comparison of the electrophysiology of the output of the basal ganglia between the two conditions. We use the natural experiment offered by Deep Brain Stimulation to compare GPi local field potential responses in subjects with Parkinson's disease compared to subjects with dystonia performing a forced-choice decision-making task with sensory feedback. In dystonic subjects, we found that auditory feedback was associated with the presence of high gamma oscillations nestled on a negative deflection, morphologically similar to sharp wave ripple complexes described in human rhinal cortex. These were not present in Parkinson's disease subjects. The temporal properties of the high gamma burst were modified by incorrect trial performance compared to correct trial performance. Both groups exhibited a robust low frequency response to 'incorrect' trial performance in dominant GPi but not non-dominant GPi at theta frequency. Our results suggest that cellular processes associated with striatum-dependent memory function may be selectively impaired in Parkinson's disease even if dopaminergic drugs are administered, but that error detection mechanisms are preserved. Twit Text FOAVip The Cognitive Role of the Globus Pallidus interna; Insights from Disease States ????Exp Brain Res http://www.kidney.de/pget.php?&tw=1&pmid=28246967 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28246967 #FOAvip English Wikipedia <ref>{{Cite pmid|28246967 }}</ref> The Cognitive Role of the Globus Pallidus interna; Insights from Disease States #MMPMID28246967 Gillies MJ ; Hyam JA ; Weiss AR ; Antoniades CA ; Bogacz R ; Fitzgerald JJ ; Aziz TZ ; Whittington MA ; Green AL Exp Brain Res 2017[May]; 235 (5 ): 1455-1465 PMID28246967 show ga The motor symptoms of both Parkinson's disease and focal dystonia arise from dysfunction of the basal ganglia, and are improved by pallidotomy or deep brain stimulation of the Globus Pallidus interna (GPi). However, Parkinson's disease is associated with a greater degree of basal ganglia-dependent learning impairment than dystonia. We attempt to understand this observation in terms of a comparison of the electrophysiology of the output of the basal ganglia between the two conditions. We use the natural experiment offered by Deep Brain Stimulation to compare GPi local field potential responses in subjects with Parkinson's disease compared to subjects with dystonia performing a forced-choice decision-making task with sensory feedback. In dystonic subjects, we found that auditory feedback was associated with the presence of high gamma oscillations nestled on a negative deflection, morphologically similar to sharp wave ripple complexes described in human rhinal cortex. These were not present in Parkinson's disease subjects. The temporal properties of the high gamma burst were modified by incorrect trial performance compared to correct trial performance. Both groups exhibited a robust low frequency response to 'incorrect' trial performance in dominant GPi but not non-dominant GPi at theta frequency. Our results suggest that cellular processes associated with striatum-dependent memory function may be selectively impaired in Parkinson's disease even if dopaminergic drugs are administered, but that error detection mechanisms are preserved. |Adult [MESH] |Aged [MESH] |Cognition/*physiology [MESH] |Deep Brain Stimulation/*methods [MESH] |Dystonic Disorders/diagnostic imaging/*therapy [MESH] |Evoked Potentials/physiology [MESH] |Female [MESH] |Globus Pallidus/diagnostic imaging/*physiology [MESH] |Humans [MESH] |Magnetic Resonance Imaging [MESH] |Male [MESH] |Middle Aged [MESH] |Neuropsychological Tests [MESH] |Parkinson Disease/diagnostic imaging/*therapy [MESH] |Physical Stimulation [MESH] |Reaction Time/physiology [MESH] |Tomography Scanners, X-Ray Computed [MESH]The Cognitive Role of the Globus Pallidus interna; Insights from Disea(epmc).pdf DeepDyve Pubget Overpricing