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2020 ; 11
(ä): 1446
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The COVID-19 Cytokine Storm; What We Know So Far
#MMPMID32612617
Ragab D
; Salah Eldin H
; Taeimah M
; Khattab R
; Salem R
Front Immunol
2020[]; 11
(ä): 1446
PMID32612617
show ga
COVID-19 is a rapidly spreading global threat that has been declared as a
pandemic by the WHO. COVID-19 is transmitted via droplets or direct contact and
infects the respiratory tract resulting in pneumonia in most of the cases and
acute respiratory distress syndrome (ARDS) in about 15 % of the cases. Mortality
in COVID-19 patients has been linked to the presence of the so-called "cytokine
storm" induced by the virus. Excessive production of proinflammatory cytokines
leads to ARDS aggravation and widespread tissue damage resulting in multi-organ
failure and death. Targeting cytokines during the management of COVID-19 patients
could improve survival rates and reduce mortality.
|Antibodies, Monoclonal, Humanized/therapeutic use
[MESH]