Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=30023410
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\30023410
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Cell+Mol+Gastroenterol+Hepatol
2018 ; 6
(2
): 133-148
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
The Brain-Gut-Microbiome Axis
#MMPMID30023410
Martin CR
; Osadchiy V
; Kalani A
; Mayer EA
Cell Mol Gastroenterol Hepatol
2018[]; 6
(2
): 133-148
PMID30023410
show ga
Preclinical and clinical studies have shown bidirectional interactions within the
brain-gut-microbiome axis. Gut microbes communicate to the central nervous system
through at least 3 parallel and interacting channels involving nervous,
endocrine, and immune signaling mechanisms. The brain can affect the community
structure and function of the gut microbiota through the autonomic nervous
system, by modulating regional gut motility, intestinal transit and secretion,
and gut permeability, and potentially through the luminal secretion of hormones
that directly modulate microbial gene expression. A systems biological model is
proposed that posits circular communication loops amid the brain, gut, and gut
microbiome, and in which perturbation at any level can propagate dysregulation
throughout the circuit. A series of largely preclinical observations implicates
alterations in brain-gut-microbiome communication in the pathogenesis and
pathophysiology of irritable bowel syndrome, obesity, and several psychiatric and
neurologic disorders. Continued research holds the promise of identifying novel
therapeutic targets and developing treatment strategies to address some of the
most debilitating, costly, and poorly understood diseases.
free
free
free
