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2015 ; 43
(Database issue
): D470-8
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English Wikipedia
The BioGRID interaction database: 2015 update
#MMPMID25428363
Chatr-Aryamontri A
; Breitkreutz BJ
; Oughtred R
; Boucher L
; Heinicke S
; Chen D
; Stark C
; Breitkreutz A
; Kolas N
; O'Donnell L
; Reguly T
; Nixon J
; Ramage L
; Winter A
; Sellam A
; Chang C
; Hirschman J
; Theesfeld C
; Rust J
; Livstone MS
; Dolinski K
; Tyers M
Nucleic Acids Res
2015[Jan]; 43
(Database issue
): D470-8
PMID25428363
show ga
The Biological General Repository for Interaction Datasets (BioGRID:
http://thebiogrid.org) is an open access database that houses genetic and protein
interactions curated from the primary biomedical literature for all major model
organism species and humans. As of September 2014, the BioGRID contains 749,912
interactions as drawn from 43,149 publications that represent 30 model organisms.
This interaction count represents a 50% increase compared to our previous 2013
BioGRID update. BioGRID data are freely distributed through partner model
organism databases and meta-databases and are directly downloadable in a variety
of formats. In addition to general curation of the published literature for the
major model species, BioGRID undertakes themed curation projects in areas of
particular relevance for biomedical sciences, such as the ubiquitin-proteasome
system and various human disease-associated interaction networks. BioGRID
curation is coordinated through an Interaction Management System (IMS) that
facilitates the compilation interaction records through structured evidence
codes, phenotype ontologies, and gene annotation. The BioGRID architecture has
been improved in order to support a broader range of interaction and
post-translational modification types, to allow the representation of more
complex multi-gene/protein interactions, to account for cellular phenotypes
through structured ontologies, to expedite curation through semi-automated
text-mining approaches, and to enhance curation quality control.
free
free
free
