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2016 ; 62
(5
): 728-44
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The Aging Epigenome
#MMPMID27259204
Booth LN
; Brunet A
Mol Cell
2016[Jun]; 62
(5
): 728-44
PMID27259204
show ga
During aging, the mechanisms that normally maintain health and stress resistance
strikingly decline, resulting in decrepitude, frailty, and ultimately death.
Exactly when and how this decline occurs is unknown. Changes in transcriptional
networks and chromatin state lie at the heart of age-dependent decline. These
epigenomic changes are not only observed during aging but also profoundly affect
cellular function and stress resistance, thereby contributing to the progression
of aging. We propose that the dysregulation of transcriptional and chromatin
networks is a crucial component of aging. Understanding age-dependent epigenomic
changes will yield key insights into how aging begins and progresses and should
lead to the development of new therapeutics that delay or even reverse aging and
age-related diseases.
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