Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1371/journal.pone.0162842 http://scihub22266oqcxt.onion/10.1371/journal.pone.0162842 C5019370!5019370 !27618436     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27618436 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27618436 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       PLoS+One 2016 ; 11 (9 ): e0162842 Nephropedia Template TP {{tp|p=27618436 |t=2016. The 9aaTAD Transactivation Domains: From Gal4 to p53 |pdf=|usr=}}{{27618436 }} gab.com Text The 9aaTAD Transactivation Domains: From Gal4 to p53 JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=27618436 #FOAvip The family of the Nine amino acid Transactivation Domain, 9aaTAD family, comprises currently over 40 members. The 9aaTAD domains are universally recognized by the transcriptional machinery from yeast to man. We had identified the 9aaTAD domains in the p53, Msn2, Pdr1 and B42 activators by our prediction algorithm. In this study, their competence to activate transcription as small peptides was proven. Not surprisingly, we elicited immense 9aaTAD divergence in hundreds of identified orthologs and numerous examples of the 9aaTAD species' convergence. We found unforeseen similarity of the mammalian p53 with yeast Gal4 9aaTAD domains. Furthermore, we identified artificial 9aaTAD domains generated accidentally by others. From an evolutionary perspective, the observed easiness to generate 9aaTAD transactivation domains indicates the natural advantage for spontaneous generation of transcription factors from DNA binding precursors. Twit Text FOAVip The 9aaTAD Transactivation Domains: From Gal4 to p53 ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=27618436 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27618436 #FOAvip English Wikipedia <ref>{{Cite pmid|27618436 }}</ref> The 9aaTAD Transactivation Domains: From Gal4 to p53 #MMPMID27618436 Piskacek M ; Havelka M ; Rezacova M ; Knight A PLoS One 2016[]; 11 (9 ): e0162842 PMID27618436 show ga The family of the Nine amino acid Transactivation Domain, 9aaTAD family, comprises currently over 40 members. The 9aaTAD domains are universally recognized by the transcriptional machinery from yeast to man. We had identified the 9aaTAD domains in the p53, Msn2, Pdr1 and B42 activators by our prediction algorithm. In this study, their competence to activate transcription as small peptides was proven. Not surprisingly, we elicited immense 9aaTAD divergence in hundreds of identified orthologs and numerous examples of the 9aaTAD species' convergence. We found unforeseen similarity of the mammalian p53 with yeast Gal4 9aaTAD domains. Furthermore, we identified artificial 9aaTAD domains generated accidentally by others. From an evolutionary perspective, the observed easiness to generate 9aaTAD transactivation domains indicates the natural advantage for spontaneous generation of transcription factors from DNA binding precursors. |*Transcriptional Activation [MESH] |Amino Acid Sequence [MESH] |DNA-Binding Proteins/*chemistry [MESH] |Saccharomyces cerevisiae Proteins/*chemistry [MESH] |Saccharomyces cerevisiae/*genetics [MESH] |Sequence Homology, Amino Acid [MESH] |Transcription Factors/*chemistry [MESH]The 9aaTAD Transactivation Domains: From Gal4 to p53 (epmc).pdf DeepDyve Pubget Overpricing