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10.1016/j.stem.2014.05.017 http://scihub22266oqcxt.onion/10.1016/j.stem.2014.05.017 C4107214!4107214 !24905166     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24905166 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24905166 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Stem+Cell 2014 ; 14 (6 ): 762-75 Nephropedia Template TP {{tp|p=24905166 |t=2014. The 3D genome in transcriptional regulation and pluripotency |pdf=|usr=}}{{24905166 }} gab.com Text The 3D genome in transcriptional regulation and pluripotency JO: Cell Stem Cell http://www.kidney.de/pget.php?&tw=1&pmid=24905166 #FOAvip It can be convenient to think of the genome as simply a string of nucleotides, the linear order of which encodes an organism's genetic blueprint. However, the genome does not exist as a linear entity within cells where this blueprint is actually utilized. Inside the nucleus, the genome is organized in three-dimensional (3D) space, and lineage-specific transcriptional programs that direct stem cell fate are implemented in this native 3D context. Here, we review principles of 3D genome organization in mammalian cells. We focus on the emerging relationship between genome organization and lineage-specific transcriptional regulation, which we argue are inextricably linked. Twit Text FOAVip The 3D genome in transcriptional regulation and pluripotency ????Cell Stem Cell http://www.kidney.de/pget.php?&tw=1&pmid=24905166 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24905166 #FOAvip English Wikipedia <ref>{{Cite pmid|24905166 }}</ref> The 3D genome in transcriptional regulation and pluripotency #MMPMID24905166 Gorkin DU ; Leung D ; Ren B Cell Stem Cell 2014[Jun]; 14 (6 ): 762-75 PMID24905166 show ga It can be convenient to think of the genome as simply a string of nucleotides, the linear order of which encodes an organism's genetic blueprint. However, the genome does not exist as a linear entity within cells where this blueprint is actually utilized. Inside the nucleus, the genome is organized in three-dimensional (3D) space, and lineage-specific transcriptional programs that direct stem cell fate are implemented in this native 3D context. Here, we review principles of 3D genome organization in mammalian cells. We focus on the emerging relationship between genome organization and lineage-specific transcriptional regulation, which we argue are inextricably linked. |Animals [MESH] |Cell Differentiation/genetics [MESH] |Cell Lineage/genetics [MESH] |Gene Expression Regulation/*genetics [MESH] |Genome/*genetics [MESH] |Humans [MESH] |Pluripotent Stem Cells/cytology/*metabolism [MESH]The 3D genome in transcriptional regulation and pluripotency (epmc).pdf DeepDyve Pubget Overpricing