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The "domestication syndrome" in mammals: a unified explanation based on neural
crest cell behavior and genetics
#MMPMID25024034
Wilkins AS
; Wrangham RW
; Fitch WT
Genetics
2014[Jul]; 197
(3
): 795-808
PMID25024034
show ga
Charles Darwin, while trying to devise a general theory of heredity from the
observations of animal and plant breeders, discovered that domesticated mammals
possess a distinctive and unusual suite of heritable traits not seen in their
wild progenitors. Some of these traits also appear in domesticated birds and
fish. The origin of Darwin's "domestication syndrome" has remained a conundrum
for more than 140 years. Most explanations focus on particular traits, while
neglecting others, or on the possible selective factors involved in domestication
rather than the underlying developmental and genetic causes of these traits.
Here, we propose that the domestication syndrome results predominantly from mild
neural crest cell deficits during embryonic development. Most of the modified
traits, both morphological and physiological, can be readily explained as direct
consequences of such deficiencies, while other traits are explicable as indirect
consequences. We first show how the hypothesis can account for the multiple,
apparently unrelated traits of the syndrome and then explore its genetic
dimensions and predictions, reviewing the available genetic evidence. The article
concludes with a brief discussion of some genetic and developmental questions
raised by the idea, along with specific predictions and experimental tests.
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