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10.1007/s13577-025-01316-6 http://scihub22266oqcxt.onion/10.1007/s13577-025-01316-6 41219639!?!41219639 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=41219639&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Hum+Cell 2025 ; 39 (1): 4 Nephropedia Template TP {{tp|p=41219639|t=2025. The "dual personality" of LOXL3: a tumor accomplice and a new hope for immunotherapy |pdf=|usr=}}{{41219639}} gab.com Text The "dual personality" of LOXL3: a tumor accomplice and a new hope for immunotherapy JO: Hum Cell http://www.kidney.de/pget.php?&tw=1&pmid=41219639 #FOAvip The lysyl oxidase family is a group of copper-containing amine oxidases involved in the remodeling of the extracellular matrix, and regulates cell signaling, metabolism, organ development, and immunity by modifying the cellular matrix. Among them, LOXL3 had been shown to regulate the proliferation, migration, and invasion of breast, colorectal, lung, melanoma, and gastric cancers. Differential expression of LOXL3 in tumor affects tumor progression by modulating immune microenvironment, where LOXL3 plays a role in regulating immune cell infiltration, immune checkpoints, and the establishment of tumor drug resistance. Here, we summarize the structure, mechanism, and functional role of LOXL3 in tumor and tumor immune microenvironment. Further, we explored strategies to improve the immunotherapy efficacy by targeting LOXL3 in tumor. Based on its properties in immunity, we explored strategies to improve the immune efficacy of LOXL3 in immunotherapy. Twit Text FOAVip The "dual personality" of LOXL3: a tumor accomplice and a new hope for immunotherapy ????Hum Cell http://www.kidney.de/pget.php?&tw=1&pmid=41219639 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=41219639 #FOAvip English Wikipedia <ref>{{Cite pmid|41219639}}</ref> The "dual personality" of LOXL3: a tumor accomplice and a new hope for immunotherapy #MMPMID41219639 Wu S; Huang C Hum Cell 2025[Nov]; 39 (1): 4 PMID41219639show ga The lysyl oxidase family is a group of copper-containing amine oxidases involved in the remodeling of the extracellular matrix, and regulates cell signaling, metabolism, organ development, and immunity by modifying the cellular matrix. Among them, LOXL3 had been shown to regulate the proliferation, migration, and invasion of breast, colorectal, lung, melanoma, and gastric cancers. Differential expression of LOXL3 in tumor affects tumor progression by modulating immune microenvironment, where LOXL3 plays a role in regulating immune cell infiltration, immune checkpoints, and the establishment of tumor drug resistance. Here, we summarize the structure, mechanism, and functional role of LOXL3 in tumor and tumor immune microenvironment. Further, we explored strategies to improve the immunotherapy efficacy by targeting LOXL3 in tumor. Based on its properties in immunity, we explored strategies to improve the immune efficacy of LOXL3 in immunotherapy. |*Amino Acid Oxidoreductases/physiology/genetics/immunology/chemistry[MESH] |*Immunotherapy/methods[MESH] |*Neoplasms/therapy/immunology/genetics/pathology[MESH] |Animals[MESH] |Cell Movement/genetics[MESH] |Cell Proliferation/genetics[MESH] |Drug Resistance, Neoplasm/genetics[MESH] |Extracellular Matrix[MESH] |Humans[MESH] |Neoplasm Invasiveness/genetics[MESH]The "dual personality" of LOXL3: a tumor accomplice and a new hope for(epmc).pdf DeepDyve Pubget Overpricing