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10.1038/ncomms11596 http://scihub22266oqcxt.onion/10.1038/ncomms11596 C4899615!4899615 !27273006     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27273006 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27273006 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2016 ; 7 (ä): 11596 Nephropedia Template TP {{tp|p=27273006 |t=2016. Th2 and eosinophil responses suppress inflammatory arthritis |pdf=|usr=}}{{27273006 }} gab.com Text Th2 and eosinophil responses suppress inflammatory arthritis JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=27273006 #FOAvip Th2-eosinophil immune responses are well known for mediating host defence against helminths. Herein we describe a function of Th2-eosinophil responses in counteracting the development of arthritis. In two independent models of arthritis, Nippostrongylus brasiliensis infection leads to Th2 and eosinophil accumulation in the joints associated with robust inhibition of arthritis and protection from bone loss. Mechanistically, this protective effect is dependent on IL-4/IL-13-induced STAT6 pathway. Furthermore, we show that eosinophils play a central role in the modulation of arthritis probably through the increase of anti-inflammatory macrophages into arthritic joints. The presence of these pathways in human disease is confirmed by detection of GATA3-positive cells and eosinophils in the joints of rheumatoid arthritis patients. Taken together, these results demonstrate that eosinophils and helminth-induced activation of the Th2 pathway axis effectively mitigate the course of inflammatory arthritis. Twit Text FOAVip Th2 and eosinophil responses suppress inflammatory arthritis ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=27273006 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27273006 #FOAvip English Wikipedia <ref>{{Cite pmid|27273006 }}</ref> Th2 and eosinophil responses suppress inflammatory arthritis #MMPMID27273006 Chen Z ; Andreev D ; Oeser K ; Krljanac B ; Hueber A ; Kleyer A ; Voehringer D ; Schett G ; Bozec A Nat Commun 2016[Jun]; 7 (ä): 11596 PMID27273006 show ga Th2-eosinophil immune responses are well known for mediating host defence against helminths. Herein we describe a function of Th2-eosinophil responses in counteracting the development of arthritis. In two independent models of arthritis, Nippostrongylus brasiliensis infection leads to Th2 and eosinophil accumulation in the joints associated with robust inhibition of arthritis and protection from bone loss. Mechanistically, this protective effect is dependent on IL-4/IL-13-induced STAT6 pathway. Furthermore, we show that eosinophils play a central role in the modulation of arthritis probably through the increase of anti-inflammatory macrophages into arthritic joints. The presence of these pathways in human disease is confirmed by detection of GATA3-positive cells and eosinophils in the joints of rheumatoid arthritis patients. Taken together, these results demonstrate that eosinophils and helminth-induced activation of the Th2 pathway axis effectively mitigate the course of inflammatory arthritis. |Animals [MESH] |Arthritis/*complications/*immunology/parasitology/pathology [MESH] |Biomarkers/metabolism [MESH] |Cell Count [MESH] |Eosinophilia/complications/pathology [MESH] |Eosinophils/*immunology [MESH] |Humans [MESH] |Inflammation/*complications/*immunology/parasitology/pathology [MESH] |Interleukin-13/metabolism [MESH] |Interleukin-4/metabolism [MESH] |Joints/pathology [MESH] |Macrophages/metabolism/pathology [MESH] |Mice, Inbred BALB C [MESH] |Mice, Inbred C57BL [MESH] |Mice, Transgenic [MESH] |Nippostrongylus/physiology [MESH] |STAT6 Transcription Factor/metabolism [MESH] |Strongylida Infections/complications/immunology/parasitology/pathology [MESH] |Th2 Cells/*immunology [MESH]Th2 and eosinophil responses suppress inflammatory arthritis (epmc).pdf DeepDyve Pubget Overpricing