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Tetraspanins Function as Regulators of Cellular Signaling
#MMPMID28428953
Termini CM
; Gillette JM
Front Cell Dev Biol
2017[]; 5
(?): 34
PMID28428953
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Tetraspanins are molecular scaffolds that distribute proteins into highly
organized microdomains consisting of adhesion, signaling, and adaptor proteins.
Many reports have identified interactions between tetraspanins and signaling
molecules, finding unique downstream cellular consequences. In this review, we
will explore these interactions as well as the specific cellular responses to
signal activation, focusing on tetraspanin regulation of adhesion-mediated
(integrins/FAK), receptor-mediated (EGFR, TNF-?, c-Met, c-Kit), and intracellular
signaling (PKC, PI4K, ?-catenin). Additionally, we will summarize our current
understanding for how tetraspanin post-translational modifications
(palmitoylation, N-linked glycosylation, and ubiquitination) can regulate signal
propagation. Many of the studies outlined in this review suggest that
tetraspanins offer a potential therapeutic target to modulate aberrant signal
transduction pathways that directly impact a host of cellular behaviors and
disease states.
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