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10.1089/ars.2013.5566 http://scihub22266oqcxt.onion/10.1089/ars.2013.5566 C4038990!4038990 !24294830     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24294830 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Antioxid+Redox+Signal 2014 ; 20 (18 ): 3040-77 Nephropedia Template TP {{tp|p=24294830 |t=2014. Tetrahydrobiopterin in cardiovascular health and disease |pdf=|usr=}}{{24294830 }} gab.com Text Tetrahydrobiopterin in cardiovascular health and disease JO: Antioxid Redox Signal http://www.kidney.de/pget.php?&tw=1&pmid=24294830 #FOAvip Tetrahydrobiopterin (BH4) functions as a cofactor for several important enzyme systems, and considerable evidence implicates BH4 as a key regulator of endothelial nitric oxide synthase (eNOS) in the setting of cardiovascular health and disease. BH4 bioavailability is determined by a balance of enzymatic de novo synthesis and recycling, versus degradation in the setting of oxidative stress. Augmenting vascular BH4 levels by pharmacological supplementation has been shown in experimental studies to enhance NO bioavailability. However, it has become more apparent that the role of BH4 in other enzymatic pathways, including other NOS isoforms and the aromatic amino acid hydroxylases, may have a bearing on important aspects of vascular homeostasis, inflammation, and cardiac function. This article reviews the role of BH4 in cardiovascular development and homeostasis, as well as in pathophysiological processes such as endothelial and vascular dysfunction, atherosclerosis, inflammation, and cardiac hypertrophy. We discuss the therapeutic potential of BH4 in cardiovascular disease states and attempt to address how this modulator of intracellular NO-redox balance may ultimately provide a powerful new treatment for many cardiovascular diseases. Twit Text FOAVip Tetrahydrobiopterin in cardiovascular health and disease ????Antioxid Redox Signal http://www.kidney.de/pget.php?&tw=1&pmid=24294830 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24294830 #FOAvip English Wikipedia <ref>{{Cite pmid|24294830 }}</ref> Tetrahydrobiopterin in cardiovascular health and disease #MMPMID24294830 Bendall JK ; Douglas G ; McNeill E ; Channon KM ; Crabtree MJ Antioxid Redox Signal 2014[Jun]; 20 (18 ): 3040-77 PMID24294830 show ga Tetrahydrobiopterin (BH4) functions as a cofactor for several important enzyme systems, and considerable evidence implicates BH4 as a key regulator of endothelial nitric oxide synthase (eNOS) in the setting of cardiovascular health and disease. BH4 bioavailability is determined by a balance of enzymatic de novo synthesis and recycling, versus degradation in the setting of oxidative stress. Augmenting vascular BH4 levels by pharmacological supplementation has been shown in experimental studies to enhance NO bioavailability. However, it has become more apparent that the role of BH4 in other enzymatic pathways, including other NOS isoforms and the aromatic amino acid hydroxylases, may have a bearing on important aspects of vascular homeostasis, inflammation, and cardiac function. This article reviews the role of BH4 in cardiovascular development and homeostasis, as well as in pathophysiological processes such as endothelial and vascular dysfunction, atherosclerosis, inflammation, and cardiac hypertrophy. We discuss the therapeutic potential of BH4 in cardiovascular disease states and attempt to address how this modulator of intracellular NO-redox balance may ultimately provide a powerful new treatment for many cardiovascular diseases. |Atherosclerosis/metabolism [MESH] |Biopterins/*analogs & derivatives/metabolism [MESH] |Cardiomegaly/metabolism [MESH] |Cardiovascular Diseases/*metabolism [MESH] |Cardiovascular System/*metabolism [MESH] |Humans [MESH] |Inflammation/metabolism [MESH] |Nitric Oxide Synthase Type III/metabolism [MESH]Tetrahydrobiopterin in cardiovascular health and disease (epmc).pdf DeepDyve Pubget Overpricing