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2016 ; 6
(ä): 37103
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Terahertz molecular resonance of cancer DNA
#MMPMID27845398
Cheon H
; Yang HJ
; Lee SH
; Kim YA
; Son JH
Sci Rep
2016[Nov]; 6
(ä): 37103
PMID27845398
show ga
Carcinogenesis involves the chemical and structural alteration of biomolecules in
cells. Aberrant methylation of DNA is a well-known carcinogenic mechanism and a
common chemical modification of DNA. Terahertz waves can directly observe changes
in DNA because the characteristic energies lie in the same frequency region. In
addition, terahertz energy levels are not high enough to damage DNA by
ionization. Here, we present terahertz molecular resonance fingerprints of DNA
methylation in cancer DNA. Methylated cytidine, a nucleoside, has terahertz
characteristic energies that give rise to the molecular resonance of methylation
in DNA. Molecular resonance is monitored in aqueous solutions of genomic DNA from
cancer cell lines using a terahertz time-domain spectroscopic technique.
Resonance signals can be quantified to identify the types of cancer cells with a
certain degree of DNA methylation. These measurements reveal the existence of
molecular resonance fingerprints of cancer DNAs in the terahertz region, which
can be utilized for the early diagnosis of cancer cells at the molecular level.