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10.1038/cddis.2017.25 http://scihub22266oqcxt.onion/10.1038/cddis.2017.25 C5386474!5386474 !28182004     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28182004 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Death+Dis 2017 ; 8 (2 ): e2608 Nephropedia Template TP {{tp|p=28182004 |t=2017. Tenovin-6 impairs autophagy by inhibiting autophagic flux |pdf=|usr=}}{{28182004 }} gab.com Text Tenovin-6 impairs autophagy by inhibiting autophagic flux JO: Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=28182004 #FOAvip Tenovin-6 has attracted significant interest because it activates p53 and inhibits sirtuins. It has anti-neoplastic effects on multiple hematopoietic malignancies and solid tumors in both in vitro and in vivo studies. Tenovin-6 was recently shown to impair the autophagy pathway in chronic lymphocytic leukemia cells and pediatric soft tissue sarcoma cells. However, whether tenovin-6 has a general inhibitory effect on autophagy and whether there is any involvement with SIRT1 and p53, both of which are regulators of the autophagy pathway, remain unclear. In this study, we have demonstrated that tenovin-6 increases microtubule-associated protein 1 light chain 3 (LC3-II) level in diverse cell types in a time- and dose-dependent manner. Mechanistically, the increase of LC3-II by tenovin-6 is caused by inhibition of the classical autophagy pathway via impairing lysosomal function without affecting the fusion between autophagosomes and lysosomes. Furthermore, we have revealed that tenovin-6 activation of p53 is cell type dependent, and tenovin-6 inhibition of autophagy is not dependent on its regulatory functions on p53 and SIRT1. Our results have shown that tenovin-6 is a potent autophagy inhibitor, and raised the precaution in interpreting results where tenovin-6 is used as an inhibitor of SIRT1. Twit Text FOAVip Tenovin-6 impairs autophagy by inhibiting autophagic flux ????Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=28182004 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28182004 #FOAvip English Wikipedia <ref>{{Cite pmid|28182004 }}</ref> Tenovin-6 impairs autophagy by inhibiting autophagic flux #MMPMID28182004 Yuan H ; Tan B ; Gao SJ Cell Death Dis 2017[Feb]; 8 (2 ): e2608 PMID28182004 show ga Tenovin-6 has attracted significant interest because it activates p53 and inhibits sirtuins. It has anti-neoplastic effects on multiple hematopoietic malignancies and solid tumors in both in vitro and in vivo studies. Tenovin-6 was recently shown to impair the autophagy pathway in chronic lymphocytic leukemia cells and pediatric soft tissue sarcoma cells. However, whether tenovin-6 has a general inhibitory effect on autophagy and whether there is any involvement with SIRT1 and p53, both of which are regulators of the autophagy pathway, remain unclear. In this study, we have demonstrated that tenovin-6 increases microtubule-associated protein 1 light chain 3 (LC3-II) level in diverse cell types in a time- and dose-dependent manner. Mechanistically, the increase of LC3-II by tenovin-6 is caused by inhibition of the classical autophagy pathway via impairing lysosomal function without affecting the fusion between autophagosomes and lysosomes. Furthermore, we have revealed that tenovin-6 activation of p53 is cell type dependent, and tenovin-6 inhibition of autophagy is not dependent on its regulatory functions on p53 and SIRT1. Our results have shown that tenovin-6 is a potent autophagy inhibitor, and raised the precaution in interpreting results where tenovin-6 is used as an inhibitor of SIRT1. |A549 Cells [MESH] |Autophagosomes/metabolism [MESH] |Autophagy/*physiology [MESH] |Benzamides/*metabolism [MESH] |Cell Line [MESH] |Cell Line, Tumor [MESH] |HEK293 Cells [MESH] |Humans [MESH] |Leukemia, Lymphocytic, Chronic, B-Cell/metabolism [MESH] |Lysosomes/metabolism [MESH] |Microtubule-Associated Proteins/metabolism [MESH] |Sirtuin 1/metabolism [MESH]Tenovin-6 impairs autophagy by inhibiting autophagic flux (epmc).pdf DeepDyve Pubget Overpricing