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2015 ; 6
(ä): 330
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Tendon Vasculature in Health and Disease
#MMPMID26635616
Tempfer H
; Traweger A
Front Physiol
2015[]; 6
(ä): 330
PMID26635616
show ga
Tendons represent a bradytrophic tissue which is poorly vascularized and,
compared to bone or skin, heal poorly. Usually, a vascularized connective scar
tissue with inferior functional properties forms at the injury site. Whether the
increased vascularization is the root cause of tissue impairments such as loss of
collagen fiber orientation, ectopic formation of bone, fat or cartilage, or is a
consequence of these pathological changes remains unclear. This review provides
an overview of the role of tendon vasculature in healthy and chronically diseased
tendon tissue as well as its relevance for tendon repair. Further, the nature and
the role of perivascular tendon stem/progenitor cells residing in the vascular
niche will be discussed and compared to multipotent stromal cells in other
tissues.