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10.17925/EE.2017.13.02.54

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suck abstract from ncbi


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pmid29632607
      Eur+Endocrinol 2017 ; 13 (2 ): 54-55
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  • Ten Years of Vildagliptin #MMPMID29632607
  • Del Prato S
  • Eur Endocrinol 2017[Aug]; 13 (2 ): 54-55 PMID29632607 show ga
  • After many years of limited therapeutic opportunities, the treatment of type 2 diabetes has become more target and pathophysiologically driven. A typical example is represented by the development of the dipeptidyl peptidase-4 (DPP-4) inhibitors, allowing for more physiological regulation of the endocrine pancreas and leading to a previously unmet risk-to-benefit balance. Vildagliptin, one of the earliest DPP-4 inhibitors, has been tested across the entire spectrum of type 2 diabetes and has been in clinical use for 20 years. This publication critically reviews the main steps in the clinical development of this agent.
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