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2017 ; 7
(1
): 16044
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Temporal depolarization of mitochondria during M phase
#MMPMID29167496
Hirusaki K
; Yokoyama K
; Cho K
; Ohta Y
Sci Rep
2017[Nov]; 7
(1
): 16044
PMID29167496
show ga
Mitochondrial activity in cells must be tightly controlled in response to changes
in intracellular circumstances. Despite drastic changes in intracellular
conditions and mitochondrial morphology, it is not clear how mitochondrial
activity is controlled during M phase of the cell cycle. Here, we show that
mitochondrial activity is drastically changed during M phase. Mitochondrial
membrane potential changed during M phase progression. Mitochondria were
polarized until metaphase to the same extent as mitochondria in interphase cells,
but were depolarized at around telophase and cytokinesis. After cytokinesis,
mitochondrial membrane potential was recovered. In addition, the generation of
superoxide anions in mitochondria was significantly reduced at metaphase even in
the presence of antimycin A, an inhibitor of complex III. These results suggest
that the electron supply to the mitochondrial electron transfer chain is
suppressed during M phase. This suppression might decrease the reactive oxygen
species generated by the fragmentation of mitochondria during M phase.
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