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2016 ; 13
(8
): 683-9
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Telomerase RNA is more than a DNA template
#MMPMID27245259
Webb CJ
; Zakian VA
RNA Biol
2016[Aug]; 13
(8
): 683-9
PMID27245259
show ga
The addition of telomeric DNA to chromosome ends is an essential cellular
activity that compensates for the loss of genomic DNA that is due to the
inability of the conventional DNA replication apparatus to duplicate the entire
chromosome. The telomerase reverse transcriptase and its associated RNA bind to
the very end of the telomere via a sequence in the RNA and specific
protein-protein interactions. Telomerase RNA also provides the template for
addition of new telomeric repeats by the reverse-transcriptase protein subunit.
In addition to the template, there are 3 other conserved regions in telomerase
RNA that are essential for normal telomerase activity. Here we briefly review the
conserved core regions of telomerase RNA and then focus on a recent study in
fission yeast that determined the function of another conserved region in
telomerase RNA called the Stem Terminus Element (STE). (1) The STE is distant
from the templating core of telomerase in both the linear and RNA secondary
structure, but, nonetheless, affects the fidelity of telomere sequence addition
and, in turn, the ability of telomere binding proteins to bind and protect
chromosome ends. We will discuss possible mechanisms of STE action and the
suitability of the STE as an anti-cancer target.
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