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2011 ; 15
(10
): 2262-8
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Telocytes in trachea and lungs
#MMPMID21810171
Zheng Y
; Li H
; Manole CG
; Sun A
; Ge J
; Wang X
J Cell Mol Med
2011[Oct]; 15
(10
): 2262-8
PMID21810171
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We show the existence of a novel type of interstitial cell-telocytes (TC) in
mouse trachea and lungs. We used cell cultures, vital stainings, as well as
scanning electron microscopy (SEM), transmission electron microscopy (TEM) and
immunohistochemistry (IHC). Phase contrast microscopy on cultured cells showed
cells with unequivocally characteristic morphology of typical TC (cells with
telopodes-Tp). SEM revealed typical TC with two to three Tp-very long and
branched cell prolongations. Tp consist of an alternation of thin segments
(podomers) and thick segments (podoms). The latter accommodate mitochondria (as
shown by Janus Green and MitoTracker), rough endoplasmic reticulum and caveolae.
TEM showed characteristic podomers and podoms as well as close relationships with
nerve endings and blood capillaries. IHC revealed positive expression of TC for
c-kit, vimentin and CD34. In conclusion, this study shows the presence in trachea
and lungs of a peculiar type of cells, which fulfils the criteria for TC.
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