Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26987685
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26987685
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Cell+Mol+Med
2016 ; 20
(5
): 973-9
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Telocytes in exercise-induced cardiac growth
#MMPMID26987685
Xiao J
; Chen P
; Qu Y
; Yu P
; Yao J
; Wang H
; Fu S
; Bei Y
; Chen Y
; Che L
; Xu J
J Cell Mol Med
2016[May]; 20
(5
): 973-9
PMID26987685
show ga
Exercise can induce physiological cardiac growth, which is featured by enlarged
cardiomyocyte cell size and formation of new cardiomyocytes. Telocytes (TCs) are
a recently identified distinct interstitial cell type, existing in many tissues
and organs including heart. TCs have been shown to form a tandem with cardiac
stem/progenitor cells in cardiac stem cell niches, participating in cardiac
regeneration and repair. Although exercise-induced cardiac growth has been
confirmed as an important way to promote cardiac regeneration and repair, the
response of cardiac TCs to exercise is still unclear. In this study, 4 weeks of
swimming training was used to induce robust healthy cardiac growth. Exercise can
induce an increase in cardiomyocyte cell size and formation of new cardiomyocytes
as determined by Wheat Germ Lectin and EdU staining respectively. TCs were
identified by three immunofluorescence stainings including double labelling for
CD34/vimentin, CD34/platelet-derived growth factor (PDGF) receptor-? and
CD34/PDGF receptor-?. We found that cardiac TCs were significantly increased in
exercised heart, suggesting that TCs might help control the activity of cardiac
stem/progenitor cells, cardiomyocytes or endothelial cells. Adding cardiac TCs
might help promote cardiac regeneration and renewal.
free
free
free
