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2014 ; 239
(11
): 1476-88
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Techniques and assays for the study of angiogenesis
#MMPMID24872440
Irvin MW
; Zijlstra A
; Wikswo JP
; Pozzi A
Exp Biol Med (Maywood)
2014[Nov]; 239
(11
): 1476-88
PMID24872440
show ga
The importance of studying angiogenesis, the formation of new blood vessels from
pre-existing vessels, is underscored by its involvement in both normal
physiology, such as embryonic growth and wound healing, and pathologies, such as
diabetes and cancer. Treatments targeting the molecular drive of angiogenesis
have been developed, but many of the molecular mechanisms that mediate
vascularization, as well as how these mechanisms can be targeted in therapy,
remain poorly understood. The limited capacity to quantify angiogenesis properly
curtails our molecular understanding and development of new drugs and therapies.
Although there are a number of assays for angiogenesis, many of them strip away
its important components and/or limit control of the variables that direct this
highly cooperative and complex process. Here we review assays commonly used in
endothelial cell biology and describe the progress toward development of a
physiologically realistic platform that will enable a better understanding of the
molecular and physical mechanisms that govern angiogenesis.
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