Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.ejca.2015.12.016 http://scihub22266oqcxt.onion/10.1016/j.ejca.2015.12.016 C4769921!4769921 !26849037     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26849037 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26849037 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Eur+J+Cancer 2016 ; 56 (ä): 131-143 Nephropedia Template TP {{tp|p=26849037 |t=2016. Targeting the tumour microenvironment in ovarian cancer |pdf=|usr=}}{{26849037 }} gab.com Text Targeting the tumour microenvironment in ovarian cancer JO: Eur J Cancer http://www.kidney.de/pget.php?&tw=1&pmid=26849037 #FOAvip The study of cancer initiation, growth, and metastasis has traditionally been focused on cancer cells, and the view that they proliferate due to uncontrolled growth signalling owing to genetic derangements. However, uncontrolled growth in tumours cannot be explained solely by aberrations in cancer cells themselves. To fully understand the biological behaviour of tumours, it is essential to understand the microenvironment in which cancer cells exist, and how they manipulate the surrounding stroma to promote the malignant phenotype. Ovarian cancer is the leading cause of death from gynaecologic cancer worldwide. The majority of patients will have objective responses to standard tumour debulking surgery and platinum-taxane doublet chemotherapy, but most will experience disease recurrence and chemotherapy resistance. As such, a great deal of effort has been put forth to develop therapies that target the tumour microenvironment in ovarian cancer. Herein, we review the key components of the tumour microenvironment as they pertain to this disease, outline targeting opportunities and supporting evidence thus far, and discuss resistance to therapy. Twit Text FOAVip Targeting the tumour microenvironment in ovarian cancer ????Eur J Cancer http://www.kidney.de/pget.php?&tw=1&pmid=26849037 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26849037 #FOAvip English Wikipedia <ref>{{Cite pmid|26849037 }}</ref> Targeting the tumour microenvironment in ovarian cancer #MMPMID26849037 Hansen JM ; Coleman RL ; Sood AK Eur J Cancer 2016[Mar]; 56 (ä): 131-143 PMID26849037 show ga The study of cancer initiation, growth, and metastasis has traditionally been focused on cancer cells, and the view that they proliferate due to uncontrolled growth signalling owing to genetic derangements. However, uncontrolled growth in tumours cannot be explained solely by aberrations in cancer cells themselves. To fully understand the biological behaviour of tumours, it is essential to understand the microenvironment in which cancer cells exist, and how they manipulate the surrounding stroma to promote the malignant phenotype. Ovarian cancer is the leading cause of death from gynaecologic cancer worldwide. The majority of patients will have objective responses to standard tumour debulking surgery and platinum-taxane doublet chemotherapy, but most will experience disease recurrence and chemotherapy resistance. As such, a great deal of effort has been put forth to develop therapies that target the tumour microenvironment in ovarian cancer. Herein, we review the key components of the tumour microenvironment as they pertain to this disease, outline targeting opportunities and supporting evidence thus far, and discuss resistance to therapy. |*Molecular Targeted Therapy [MESH] |Angiogenesis Inhibitors/therapeutic use [MESH] |Animals [MESH] |Antineoplastic Agents/*therapeutic use [MESH] |Carcinoma, Ovarian Epithelial [MESH] |Cell Proliferation/drug effects [MESH] |Drug Resistance, Neoplasm [MESH] |Endothelial Cells/drug effects/metabolism/pathology [MESH] |Female [MESH] |Fibroblasts/drug effects/metabolism/pathology [MESH] |Humans [MESH] |Neoplasms, Glandular and Epithelial/blood supply/*drug therapy/immunology/metabolism/pathology [MESH] |Neovascularization, Pathologic [MESH] |Ovarian Neoplasms/blood supply/*drug therapy/immunology/metabolism/pathology [MESH] |Signal Transduction/drug effects [MESH] |Tumor Burden/drug effects [MESH]Targeting the tumour microenvironment in ovarian cancer (epmc).pdf DeepDyve Pubget Overpricing