Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26491220
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Mediators+Inflamm
2015 ; 2015
(ä): 146282
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Targeting the Mitotic Catastrophe Signaling Pathway in Cancer
#MMPMID26491220
Mc Gee MM
Mediators Inflamm
2015[]; 2015
(ä): 146282
PMID26491220
show ga
Mitotic catastrophe, as defined in 2012 by the International Nomenclature
Committee on Cell Death, is a bona fide intrinsic oncosuppressive mechanism that
senses mitotic failure and responds by driving a cell to an irreversible
antiproliferative fate of death or senescence. Thus, failed mitotic catastrophe
can promote the unrestrained growth of defective cells, thereby representing a
major gateway to tumour development. Furthermore, the activation of mitotic
catastrophe offers significant therapeutic advantage which has been exploited in
the action of conventional and targeted anticancer agents. Yet, despite its
importance in tumour prevention and treatment, the molecular mechanism of mitotic
catastrophe is not well understood. A better understanding of the signals that
determine cell fate following failed or defective mitosis will reveal new
opportunities to selectively target and enhance the programme for therapeutic
benefit and reveal biomarkers to predict patient response. This review is focused
on the molecular mechanism of mitotic catastrophe induction and signalling and
highlights current strategies to exploit the process in cancer therapy.
free
free
free
