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10.3390/biom5031912 http://scihub22266oqcxt.onion/10.3390/biom5031912 C4598780!4598780 !26295265     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26295265 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Biomolecules 2015 ; 5 (3 ): 1912-37 Nephropedia Template TP {{tp|p=26295265 |t=2015. Targeting the Checkpoint to Kill Cancer Cells |pdf=|usr=}}{{26295265 }} gab.com Text Targeting the Checkpoint to Kill Cancer Cells JO: Biomolecules http://www.kidney.de/pget.php?&tw=1&pmid=26295265 #FOAvip Cancer treatments such as radiotherapy and most of the chemotherapies act by damaging DNA of cancer cells. Upon DNA damage, cells stop proliferation at cell cycle checkpoints, which provides them time for DNA repair. Inhibiting the checkpoint allows entry to mitosis despite the presence of DNA damage and can lead to cell death. Importantly, as cancer cells exhibit increased levels of endogenous DNA damage due to an excessive replication stress, inhibiting the checkpoint kinases alone could act as a directed anti-cancer therapy. Here, we review the current status of inhibitors targeted towards the checkpoint effectors and discuss mechanisms of their actions in killing of cancer cells. Twit Text FOAVip Targeting the Checkpoint to Kill Cancer Cells ????Biomolecules http://www.kidney.de/pget.php?&tw=1&pmid=26295265 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26295265 #FOAvip English Wikipedia <ref>{{Cite pmid|26295265 }}</ref> Targeting the Checkpoint to Kill Cancer Cells #MMPMID26295265 Benada J ; Macurek L Biomolecules 2015[Aug]; 5 (3 ): 1912-37 PMID26295265 show ga Cancer treatments such as radiotherapy and most of the chemotherapies act by damaging DNA of cancer cells. Upon DNA damage, cells stop proliferation at cell cycle checkpoints, which provides them time for DNA repair. Inhibiting the checkpoint allows entry to mitosis despite the presence of DNA damage and can lead to cell death. Importantly, as cancer cells exhibit increased levels of endogenous DNA damage due to an excessive replication stress, inhibiting the checkpoint kinases alone could act as a directed anti-cancer therapy. Here, we review the current status of inhibitors targeted towards the checkpoint effectors and discuss mechanisms of their actions in killing of cancer cells. |Animals [MESH] |Cell Cycle Checkpoints/*drug effects [MESH] |Cell Death/drug effects [MESH] |Humans [MESH] |Molecular Targeted Therapy/*methods [MESH] |Neoplasms/*drug therapy/enzymology/metabolism/*pathology [MESH] |Protein Kinase Inhibitors/pharmacology/therapeutic use [MESH]Targeting the Checkpoint to Kill Cancer Cells (epmc).pdf DeepDyve Pubget Overpricing