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10.1038/nn.3427 http://scihub22266oqcxt.onion/10.1038/nn.3427 C4928704!4928704 !23799473     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\23799473 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Neurosci 2013 ; 16 (7 ): 805-15 Nephropedia Template TP {{tp|p=23799473 |t=2013. Targeting neurons and photons for optogenetics |pdf=|usr=}}{{23799473 }} gab.com Text Targeting neurons and photons for optogenetics JO: Nat Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=23799473 #FOAvip Optogenetic approaches promise to revolutionize neuroscience by using light to manipulate neural activity in genetically or functionally defined neurons with millisecond precision. Harnessing the full potential of optogenetic tools, however, requires light to be targeted to the right neurons at the right time. Here we discuss some barriers and potential solutions to this problem. We review methods for targeting the expression of light-activatable molecules to specific cell types, under genetic, viral or activity-dependent control. Next we explore new ways to target light to individual neurons to allow their precise activation and inactivation. These techniques provide a precision in the temporal and spatial activation of neurons that was not achievable in previous experiments. In combination with simultaneous recording and imaging techniques, these strategies will allow us to mimic the natural activity patterns of neurons in vivo, enabling previously impossible 'dream experiments'. Twit Text FOAVip Targeting neurons and photons for optogenetics ????Nat Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=23799473 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23799473 #FOAvip English Wikipedia <ref>{{Cite pmid|23799473 }}</ref> Targeting neurons and photons for optogenetics #MMPMID23799473 Packer AM ; Roska B ; Häusser M Nat Neurosci 2013[Jul]; 16 (7 ): 805-15 PMID23799473 show ga Optogenetic approaches promise to revolutionize neuroscience by using light to manipulate neural activity in genetically or functionally defined neurons with millisecond precision. Harnessing the full potential of optogenetic tools, however, requires light to be targeted to the right neurons at the right time. Here we discuss some barriers and potential solutions to this problem. We review methods for targeting the expression of light-activatable molecules to specific cell types, under genetic, viral or activity-dependent control. Next we explore new ways to target light to individual neurons to allow their precise activation and inactivation. These techniques provide a precision in the temporal and spatial activation of neurons that was not achievable in previous experiments. In combination with simultaneous recording and imaging techniques, these strategies will allow us to mimic the natural activity patterns of neurons in vivo, enabling previously impossible 'dream experiments'. |*Neurons/cytology/physiology [MESH] |*Optogenetics/instrumentation [MESH] |*Photons [MESH] |Animals [MESH] |Gene Expression [MESH] |Humans [MESH] |Models, Animal [MESH] |Nerve Net/metabolism/physiology [MESH] |Transfection [MESH]Targeting neurons and photons for optogenetics (epmc).pdf DeepDyve Pubget Overpricing