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10.1038/nrc.2016.154 http://scihub22266oqcxt.onion/10.1038/nrc.2016.154 C5575801!5575801 !28233802     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28233802 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28233802 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Rev+Cancer 2017 ; 17 (4 ): 209-222 Nephropedia Template TP {{tp|p=28233802 |t=2017. Targeting neoantigens to augment antitumour immunity |pdf=|usr=}}{{28233802 }} gab.com Text Targeting neoantigens to augment antitumour immunity JO: Nat Rev Cancer http://www.kidney.de/pget.php?&tw=1&pmid=28233802 #FOAvip The past decade of cancer research has been marked by a growing appreciation of the role of immunity in cancer. Mutations in the tumour genome can cause tumours to express mutant proteins that are tumour specific and not expressed on normal cells (neoantigens). These neoantigens are an attractive immune target because their selective expression on tumours may minimize immune tolerance as well as the risk of autoimmunity. In this Review we discuss the emerging evidence that neoantigens are recognized by the immune system and can be targeted to increase antitumour immunity. We also provide a framework for personalized cancer immunotherapy through the identification and selective targeting of individual tumour neoantigens, and present the potential benefits and obstacles to this approach of targeted immunotherapy. Twit Text FOAVip Targeting neoantigens to augment antitumour immunity ????Nat Rev Cancer http://www.kidney.de/pget.php?&tw=1&pmid=28233802 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28233802 #FOAvip English Wikipedia <ref>{{Cite pmid|28233802 }}</ref> Targeting neoantigens to augment antitumour immunity #MMPMID28233802 Yarchoan M ; Johnson BA 3rd ; Lutz ER ; Laheru DA ; Jaffee EM Nat Rev Cancer 2017[Apr]; 17 (4 ): 209-222 PMID28233802 show ga The past decade of cancer research has been marked by a growing appreciation of the role of immunity in cancer. Mutations in the tumour genome can cause tumours to express mutant proteins that are tumour specific and not expressed on normal cells (neoantigens). These neoantigens are an attractive immune target because their selective expression on tumours may minimize immune tolerance as well as the risk of autoimmunity. In this Review we discuss the emerging evidence that neoantigens are recognized by the immune system and can be targeted to increase antitumour immunity. We also provide a framework for personalized cancer immunotherapy through the identification and selective targeting of individual tumour neoantigens, and present the potential benefits and obstacles to this approach of targeted immunotherapy. |Adoptive Transfer [MESH] |Animals [MESH] |Antigens, Neoplasm/*immunology [MESH] |Humans [MESH] |Immunotherapy/*methods [MESH] |Mutation [MESH] |Neoplasms/immunology/*therapy [MESH] |Precision Medicine [MESH] |T-Lymphocytes/immunology [MESH] |Tumor Escape [MESH]Targeting neoantigens to augment antitumour immunity (epmc).pdf DeepDyve Pubget Overpricing