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10.1038/nrd.2016.248 http://scihub22266oqcxt.onion/10.1038/nrd.2016.248 C5455971!5455971 !28154410     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28154410 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28154410 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Rev+Drug+Discov 2017 ; 16 (6 ): 400-423 Nephropedia Template TP {{tp|p=28154410 |t=2017. Targeting iron metabolism in drug discovery and delivery |pdf=|usr=}}{{28154410 }} gab.com Text Targeting iron metabolism in drug discovery and delivery JO: Nat Rev Drug Discov http://www.kidney.de/pget.php?&tw=1&pmid=28154410 #FOAvip Iron fulfils a central role in many essential biochemical processes in human physiology; thus, proper processing of iron is crucial. Although iron metabolism is subject to relatively strict physiological control, numerous disorders, such as cancer and neurodegenerative diseases, have recently been linked to deregulated iron homeostasis. Consequently, iron metabolism constitutes a promising and largely unexploited therapeutic target for the development of new pharmacological treatments for these diseases. Several iron metabolism-targeted therapies are already under clinical evaluation for haematological disorders, and these and newly developed therapeutic agents are likely to have substantial benefit in the clinical management of iron metabolism-associated diseases, for which few efficacious treatments are currently available. Twit Text FOAVip Targeting iron metabolism in drug discovery and delivery ????Nat Rev Drug Discov http://www.kidney.de/pget.php?&tw=1&pmid=28154410 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28154410 #FOAvip English Wikipedia <ref>{{Cite pmid|28154410 }}</ref> Targeting iron metabolism in drug discovery and delivery #MMPMID28154410 Crielaard BJ ; Lammers T ; Rivella S Nat Rev Drug Discov 2017[Jun]; 16 (6 ): 400-423 PMID28154410 show ga Iron fulfils a central role in many essential biochemical processes in human physiology; thus, proper processing of iron is crucial. Although iron metabolism is subject to relatively strict physiological control, numerous disorders, such as cancer and neurodegenerative diseases, have recently been linked to deregulated iron homeostasis. Consequently, iron metabolism constitutes a promising and largely unexploited therapeutic target for the development of new pharmacological treatments for these diseases. Several iron metabolism-targeted therapies are already under clinical evaluation for haematological disorders, and these and newly developed therapeutic agents are likely to have substantial benefit in the clinical management of iron metabolism-associated diseases, for which few efficacious treatments are currently available. |*Drug Design [MESH] |Animals [MESH] |Drug Delivery Systems [MESH] |Drug Discovery/*methods [MESH] |Homeostasis [MESH] |Humans [MESH] |Iron/*metabolism [MESH] |Molecular Targeted Therapy [MESH] |Neoplasms/drug therapy/physiopathology [MESH]Targeting iron metabolism in drug discovery and delivery (epmc).pdf DeepDyve Pubget Overpricing