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10.1002/pro.3129 http://scihub22266oqcxt.onion/10.1002/pro.3129 C5368065!5368065 !28160335     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28160335 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Protein+Sci 2017 ; 26 (4 ): 662-676 Nephropedia Template TP {{tp|p=28160335 |t=2017. Targeting human SET1/MLL family of proteins |pdf=|usr=}}{{28160335 }} gab.com Text Targeting human SET1/MLL family of proteins JO: Protein Sci http://www.kidney.de/pget.php?&tw=1&pmid=28160335 #FOAvip The SET1 family of proteins, and in particular MLL1, are essential regulators of transcription and key mediators of normal development and disease. Here, we summarize the detailed characterization of the methyltransferase activity of SET1 complexes and the role of the key subunits, WDR5, RbBP5, ASH2L, and DPY30. We present new data on full kinetic characterization of human MLL1, MLL3, SET1A, and SET1B trimeric, tetrameric, and pentameric complexes to elaborate on substrate specificities and compare our findings with what has been reported before. We also review exciting recent work identifying potent inhibitors of oncogenic MLL1 function through disruption of protein-protein interactions within the MLL1 complex. Twit Text FOAVip Targeting human SET1/MLL family of proteins ????Protein Sci http://www.kidney.de/pget.php?&tw=1&pmid=28160335 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28160335 #FOAvip English Wikipedia <ref>{{Cite pmid|28160335 }}</ref> Targeting human SET1/MLL family of proteins #MMPMID28160335 Vedadi M ; Blazer L ; Eram MS ; Barsyte-Lovejoy D ; Arrowsmith CH ; Hajian T Protein Sci 2017[Apr]; 26 (4 ): 662-676 PMID28160335 show ga The SET1 family of proteins, and in particular MLL1, are essential regulators of transcription and key mediators of normal development and disease. Here, we summarize the detailed characterization of the methyltransferase activity of SET1 complexes and the role of the key subunits, WDR5, RbBP5, ASH2L, and DPY30. We present new data on full kinetic characterization of human MLL1, MLL3, SET1A, and SET1B trimeric, tetrameric, and pentameric complexes to elaborate on substrate specificities and compare our findings with what has been reported before. We also review exciting recent work identifying potent inhibitors of oncogenic MLL1 function through disruption of protein-protein interactions within the MLL1 complex. |Enzyme Inhibitors/*chemistry/pharmacology [MESH] |Histone-Lysine N-Methyltransferase/*antagonists & inhibitors/*chemistry/metabolism [MESH] |Humans [MESH] |Multienzyme Complexes/*antagonists & inhibitors/chemistry/metabolism [MESH]Targeting human SET1/MLL family of proteins (epmc).pdf DeepDyve Pubget Overpricing